Norway selects British-made frigates for its navy, Norwegian government says
Norway will purchase a fleet of British-built frigates to reinforce its naval strength, the government confirmed on Sunday. The move marks a decisive ...
Scientists have unveiled the structure of uMtCK, a key enzyme cancer cells use for energy, offering new insights for targeted therapies to slow tumor growth.
Cancer cells are notorious for their insatiable hunger for energy, rapidly multiplying and hijacking normal cellular functions to meet their fuel demands. One of the critical processes they exploit involves a group of enzymes called creatine kinases (CK), which are responsible for shuttling energy within cells. A specific type of CK, known as ubiquitous mitochondrial creatine kinase (uMtCK), plays a crucial role in helping cancer cells tap into and distribute energy, making it an essential target for potential cancer therapies.
In a breakthrough study, scientists from Sanford Burnham Prebys and Mayo Clinic revealed the detailed structure of human uMtCK, uncovering how its shape changes when bound to energy molecules like creatine or adenosine triphosphate (ATP). Using cutting-edge cryogenic electron microscopy (cryo-EM), the team created 3D images of the protein and its interactions, offering insights that could pave the way for developing drugs to block this crucial energy transport mechanism in cancer cells.
Their research, published in Structure on February 3, 2025, also tested an existing CK inhibitor called CKi on breast cancer cells. The results showed that CKi was effective in slowing down breast cancer cell growth, confirming the potential of targeting this pathway in cancer treatment. However, the inhibitor isn’t selective for uMtCK alone, and could disrupt other vital processes, leading to high toxicity.
Building on these findings, the researchers are now working to design more targeted inhibitors that specifically block uMtCK without affecting other cellular functions, offering the promise of more effective and less toxic cancer therapies in the future.
A powerful eruption at Japan’s Shinmoedake volcano sent an ash plume more than 3,000 metres high on Sunday morning, prompting safety warnings from authorities.
According to the German Research Centre for Geosciences (GFZ), a magnitude 5.7 earthquake struck the Oaxaca region of Mexico on Saturday.
The UK is gearing up for Exercise Pegasus 2025, its largest pandemic readiness test since COVID-19. Running from September to November, this full-scale simulation will challenge the country's response to a fast-moving respiratory outbreak.
A Polish Air Force pilot was killed on Thursday when an F-16 fighter jet crashed during a training flight ahead of the 2025 Radom International Air Show.
Zambia has formalised a strategic partnership with the International Vaccine Institute (IVI) to bolster domestic vaccine manufacturing capacity, the Zambia National Public Health Institute (ZNPHI) announced on Friday.
Four-time Tour de France winner Chris Froome was airlifted to hospital in Toulon after suffering a training crash which left him with broken ribs, a collapsed lung and a back fracture, his team Israel-Premier Tech said on Thursday (August 28).
Bulgaria reported outbreaks of highly pathogenic avian influenza on three farms in the southern part of the country, the World Organisation for Animal Health (WOAH) said on Monday, as Europe faces a seasonal upturn in the deadly disease.
Africa has unveiled a continental emergency preparedness and response plan to tackle cholera from September 2025 to February 2026.
Belarusian President Alexander Lukashenko said on Sunday he had undergone a full medical exam for the first time in his life and was found to be in good health.
You can download the AnewZ application from Play Store and the App Store.
What is your opinion on this topic?
Leave the first comment