Trump shares Aliyev’s Shusha Forum speech on Truth Social again
Donald Trump has once again shared a video clip of Azerbaijani President Ilham Aliyev’s remarks from the Shusha Global Media Forum on his Truth Soci...
Scientists have unveiled the structure of uMtCK, a key enzyme cancer cells use for energy, offering new insights for targeted therapies to slow tumor growth.
Cancer cells are notorious for their insatiable hunger for energy, rapidly multiplying and hijacking normal cellular functions to meet their fuel demands. One of the critical processes they exploit involves a group of enzymes called creatine kinases (CK), which are responsible for shuttling energy within cells. A specific type of CK, known as ubiquitous mitochondrial creatine kinase (uMtCK), plays a crucial role in helping cancer cells tap into and distribute energy, making it an essential target for potential cancer therapies.
In a breakthrough study, scientists from Sanford Burnham Prebys and Mayo Clinic revealed the detailed structure of human uMtCK, uncovering how its shape changes when bound to energy molecules like creatine or adenosine triphosphate (ATP). Using cutting-edge cryogenic electron microscopy (cryo-EM), the team created 3D images of the protein and its interactions, offering insights that could pave the way for developing drugs to block this crucial energy transport mechanism in cancer cells.
Their research, published in Structure on February 3, 2025, also tested an existing CK inhibitor called CKi on breast cancer cells. The results showed that CKi was effective in slowing down breast cancer cell growth, confirming the potential of targeting this pathway in cancer treatment. However, the inhibitor isn’t selective for uMtCK alone, and could disrupt other vital processes, leading to high toxicity.
Building on these findings, the researchers are now working to design more targeted inhibitors that specifically block uMtCK without affecting other cellular functions, offering the promise of more effective and less toxic cancer therapies in the future.
The world’s biggest dance music festival faces an unexpected setback as a fire destroys its main stage, prompting a last-minute response from organisers determined to keep the party alive in Boom, Belgium.
According to the German Research Centre for Geosciences (GFZ), a magnitude 5.7 earthquake struck the Oaxaca region of Mexico on Saturday.
China and the Association of Southeast Asian Nations will send an upgraded ‘version 3.0’ free-trade agreement to their heads of government for approval in October, Chinese Foreign Minister Wang Yi said on Saturday after regional talks in Kuala Lumpur.
A resumption of Iraq’s Kurdish oil exports is not expected in the near term, sources familiar with the matter said on Friday, despite an announcement by Iraq’s federal government a day earlier stating that shipments would resume immediately.
Chinese automaker Chery has denied an industry-ministry audit that disqualified more than $53 million in state incentives for thousands of its electric and hybrid vehicles, insisting it followed official guidance and committed no fraud.
Tech giant Google has announced a $1 billion investment to support Artificial Intelligence (AI) education and research at universities across the United States.
What shapes human nature? Why do some people act with compassion while others turn cruel? For centuries, thinkers — from philosophers and playwrights to theologians and psychologists — have grappled with these timeless questions, searching for what lies at the heart of good and evil.
A new skin cancer drug has been developed using a genetically engineered virus that targets and replicates only cancer cells. That's according to public broadcaster NHK who said that researchers in Japan found that 77.8% of those tested, improved.
Adults are inhaling around 68,000 microplastic particles each day, researchers warn, over 100 times previous estimates.
Americans will soon be able to access and share their medical records through a new “digital health tech ecosystem”, unveiled by U.S. President Donald Trump in partnership with more than 60 major technology companies.
You can download the AnewZ application from Play Store and the App Store.
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