DGCA orders inspection of Boeing fuel switches after Gujarat air crash
India’s aviation regulator has instructed all airlines to inspect fuel switch systems on Boeing aircraft following a deadly crash in Gujarat last mo...
Scientists have unveiled the structure of uMtCK, a key enzyme cancer cells use for energy, offering new insights for targeted therapies to slow tumor growth.
Cancer cells are notorious for their insatiable hunger for energy, rapidly multiplying and hijacking normal cellular functions to meet their fuel demands. One of the critical processes they exploit involves a group of enzymes called creatine kinases (CK), which are responsible for shuttling energy within cells. A specific type of CK, known as ubiquitous mitochondrial creatine kinase (uMtCK), plays a crucial role in helping cancer cells tap into and distribute energy, making it an essential target for potential cancer therapies.
In a breakthrough study, scientists from Sanford Burnham Prebys and Mayo Clinic revealed the detailed structure of human uMtCK, uncovering how its shape changes when bound to energy molecules like creatine or adenosine triphosphate (ATP). Using cutting-edge cryogenic electron microscopy (cryo-EM), the team created 3D images of the protein and its interactions, offering insights that could pave the way for developing drugs to block this crucial energy transport mechanism in cancer cells.
Their research, published in Structure on February 3, 2025, also tested an existing CK inhibitor called CKi on breast cancer cells. The results showed that CKi was effective in slowing down breast cancer cell growth, confirming the potential of targeting this pathway in cancer treatment. However, the inhibitor isn’t selective for uMtCK alone, and could disrupt other vital processes, leading to high toxicity.
Building on these findings, the researchers are now working to design more targeted inhibitors that specifically block uMtCK without affecting other cellular functions, offering the promise of more effective and less toxic cancer therapies in the future.
A series of earthquakes have struck Guatemala on Tuesday afternoon, leading authorities to advise residents to evacuate from buildings as a precaution against possible aftershocks.
Australian researchers have created a groundbreaking “biological AI” platform that could revolutionise drug discovery by rapidly evolving molecules within mammalian cells.
Dozens of international and domestic flights were cancelled or delayed after Mount Lewotobi Laki Laki erupted on Monday, but Bali’s main airport remains operational.
Authorities in North Carolina are investigating three potential storm-related deaths linked to severe flooding from the remnants of Tropical Storm Chantal, officials said Tuesday.
A man was gored and seven others injured during the adrenaline-charged second day of Spain's iconic San Fermin bull running festival in Pamplona.
Accidental poisonings among young children in the U.S. are rising sharply due to nicotine pouches and vaping, with a study warning of serious health risks and calling for stronger regulation and public awareness.
Harvard researchers have discovered a new way to stop malaria transmission—by giving mosquitoes malaria drugs that kill the parasite inside them.
The European Union is stepping up its health crisis preparedness by stockpiling essential medical supplies and boosting coordination among member states.
New artificial intelligence (AI) software is helping NHS hospitals in Hull reduce MRI scan times, enabling staff to scan more patients each day while improving accessibility for vulnerable groups.
France will impose its toughest outdoor smoking restrictions starting Monday, banning smoking at beaches, parks, playgrounds, and bus stops.
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