Scientists have unveiled the structure of uMtCK, a key enzyme cancer cells use for energy, offering new insights for targeted therapies to slow tumor growth.
Cancer cells are notorious for their insatiable hunger for energy, rapidly multiplying and hijacking normal cellular functions to meet their fuel demands. One of the critical processes they exploit involves a group of enzymes called creatine kinases (CK), which are responsible for shuttling energy within cells. A specific type of CK, known as ubiquitous mitochondrial creatine kinase (uMtCK), plays a crucial role in helping cancer cells tap into and distribute energy, making it an essential target for potential cancer therapies.
In a breakthrough study, scientists from Sanford Burnham Prebys and Mayo Clinic revealed the detailed structure of human uMtCK, uncovering how its shape changes when bound to energy molecules like creatine or adenosine triphosphate (ATP). Using cutting-edge cryogenic electron microscopy (cryo-EM), the team created 3D images of the protein and its interactions, offering insights that could pave the way for developing drugs to block this crucial energy transport mechanism in cancer cells.
Their research, published in Structure on February 3, 2025, also tested an existing CK inhibitor called CKi on breast cancer cells. The results showed that CKi was effective in slowing down breast cancer cell growth, confirming the potential of targeting this pathway in cancer treatment. However, the inhibitor isn’t selective for uMtCK alone, and could disrupt other vital processes, leading to high toxicity.
Building on these findings, the researchers are now working to design more targeted inhibitors that specifically block uMtCK without affecting other cellular functions, offering the promise of more effective and less toxic cancer therapies in the future.
Follow the latest developments and global reaction after the U.S. and Israel launched “major combat operations” in Iran, prompting reta...
Protests broke out in Pakistan and Iraq on Sunday after Iranian state media confirmed that Supreme Leader Ayatollah Ali Khamenei had been killed in...
A number of senior Iranian figures have reportedly been killed in Saturday’s joint U.S.–Israel...
Afghanistan said it had fired at Pakistani aircraft over Kabul after explosions and gunfire rocked the capital ...
The death of Iran’s Supreme Leader...
Protests broke out in Pakistan and Iraq on Sunday after Iranian state media confirmed that Supreme Leader Ayatollah Ali Khamenei had been killed in joint U.S.–Israeli strikes. At least nine people were reported dead in clashes near the U.S. consulate in Karachi.
A number of senior Iranian figures have reportedly been killed in Saturday’s joint U.S.–Israeli airstrikes on Iran, according to Iranian state media, Israeli military statements and international reporting. Some of the details remain unverified.
The death of Iran’s Supreme Leader Ayatollah Ali Khamenei has triggered one of the most significant political processes in the Islamic Republic: the selection of a new Supreme Leader.
Following the U.S.-Israel strikes, Iran has called for an urgent meeting of the United Nations Security Council to be held on Monday (2 March), and vowed strong retaliation to the attacks. Touraj Shiralilou sent this update from Tehran.
Follow the latest developments and global reaction after the U.S. and Israel launched “major combat operations” in Iran, prompting retaliation from Tehran.
Tensions between the U.S. and Iran are escalating, with Washington ordering a significant military build-up in the region and multiple countries evacuating diplomatic staff amid fears of further instability.
Governments across the region responded swiftly to Israel’s strikes on Iran, closing airspace, issuing travel advisories and activating contingency plans amid fears of escalation.
Two people were killed and around 40 injured when a tram derailed in central Milan on Friday (27 February), a spokesperson for the local fire service said.
Pakistani air strikes hit a weapons depot on the western outskirts of Kabul overnight, triggering hours of secondary explosions that rattled homes across the Afghan capital and left residents fearing further violence.
Measles cases across Europe and Central Asia fell sharply in 2025 compared to the previous year but health officials have warned that the risk of fresh outbreaks remains unless vaccination gaps are urgently addressed.
A Florida university has become a new hotspot in a widening U.S. measles outbreak, with health officials confirming multiple infections and hospitalisations.
The World Health Organization has added the Nipah virus to its list of the world’s top 10 priority diseases, alongside COVID-19 and the Zika virus, warning that its epidemic potential highlights the global risk posed by fast-spreading outbreaks.
Belgian authorities are examining suspected cases of infants falling ill after consuming recalled Nestle baby formula, amid warnings that confirmed infections may be underestimated due to limited testing requirements.
Two Nipah infections involving health workers in India have triggered heightened screening across Southeast Asia as authorities move to prevent the high fatality virus from spreading beyond the country.
You can download the AnewZ application from Play Store and the App Store.
What is your opinion on this topic?
Leave the first comment