Russia strikes Ukraine energy grid, killing six, including one child
Russia launched a large-scale overnight barrage of drones and missiles against Ukraine’s energy infrastructure, killing six people — including a s...
Scientists have unveiled the structure of uMtCK, a key enzyme cancer cells use for energy, offering new insights for targeted therapies to slow tumor growth.
Cancer cells are notorious for their insatiable hunger for energy, rapidly multiplying and hijacking normal cellular functions to meet their fuel demands. One of the critical processes they exploit involves a group of enzymes called creatine kinases (CK), which are responsible for shuttling energy within cells. A specific type of CK, known as ubiquitous mitochondrial creatine kinase (uMtCK), plays a crucial role in helping cancer cells tap into and distribute energy, making it an essential target for potential cancer therapies.
In a breakthrough study, scientists from Sanford Burnham Prebys and Mayo Clinic revealed the detailed structure of human uMtCK, uncovering how its shape changes when bound to energy molecules like creatine or adenosine triphosphate (ATP). Using cutting-edge cryogenic electron microscopy (cryo-EM), the team created 3D images of the protein and its interactions, offering insights that could pave the way for developing drugs to block this crucial energy transport mechanism in cancer cells.
Their research, published in Structure on February 3, 2025, also tested an existing CK inhibitor called CKi on breast cancer cells. The results showed that CKi was effective in slowing down breast cancer cell growth, confirming the potential of targeting this pathway in cancer treatment. However, the inhibitor isn’t selective for uMtCK alone, and could disrupt other vital processes, leading to high toxicity.
Building on these findings, the researchers are now working to design more targeted inhibitors that specifically block uMtCK without affecting other cellular functions, offering the promise of more effective and less toxic cancer therapies in the future.
Nokia announced on Tuesday that chipmaker Nvidia will acquire a $1 billion stake in the company.
Centrist liberal party D66, led by 38-year-old Rob Jetten, has made sweeping gains in the Dutch election, emerging neck and neck with Geert Wilders’ far-right Freedom Party (PVV) in early results — a stunning reversal just two years after D66 ranked sixth.
Reliable sources have confirmed to AnewZ that the United States has asked Azerbaijan to join a Stabilisation Force in Gaza, as part of a proposed international mission to secure the territory.
U.S. President Donald Trump agreed with President Xi Jinping to trim tariffs on China in exchange for Beijing cracking down on the illicit fentanyl trade, Trump said.
Ukrainian President Volodymyr Zelenskyy said on Wednesday that the most difficult situation on the front line remains the eastern city of Pokrovsk, where fighting continues to be most intense due to a strong concentration of Russian forces.
A prostate cancer blood test has been shown to reduce the risk of dying from the disease by 13% over two decades, researchers say.
Serious cases of a disorder of the large intestine are surging among Americans younger than 50, researchers say.
Russian President Vladimir Putin asked North Korean Foreign Minister Choe Son Hui during talks in the Kremlin on Monday to tell her country's leader Kim Jong Un that everything was "going to plan" in bilateral relations.
U.S. border czar says fentanyl should be considered a WMD.
U.S. states this week warned food aid recipients that their benefits may not be distributed in November if the federal government shutdown stretches into its fourth week.
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