Scientists have unveiled the structure of uMtCK, a key enzyme cancer cells use for energy, offering new insights for targeted therapies to slow tumor growth.
Cancer cells are notorious for their insatiable hunger for energy, rapidly multiplying and hijacking normal cellular functions to meet their fuel demands. One of the critical processes they exploit involves a group of enzymes called creatine kinases (CK), which are responsible for shuttling energy within cells. A specific type of CK, known as ubiquitous mitochondrial creatine kinase (uMtCK), plays a crucial role in helping cancer cells tap into and distribute energy, making it an essential target for potential cancer therapies.
In a breakthrough study, scientists from Sanford Burnham Prebys and Mayo Clinic revealed the detailed structure of human uMtCK, uncovering how its shape changes when bound to energy molecules like creatine or adenosine triphosphate (ATP). Using cutting-edge cryogenic electron microscopy (cryo-EM), the team created 3D images of the protein and its interactions, offering insights that could pave the way for developing drugs to block this crucial energy transport mechanism in cancer cells.
Their research, published in Structure on February 3, 2025, also tested an existing CK inhibitor called CKi on breast cancer cells. The results showed that CKi was effective in slowing down breast cancer cell growth, confirming the potential of targeting this pathway in cancer treatment. However, the inhibitor isn’t selective for uMtCK alone, and could disrupt other vital processes, leading to high toxicity.
Building on these findings, the researchers are now working to design more targeted inhibitors that specifically block uMtCK without affecting other cellular functions, offering the promise of more effective and less toxic cancer therapies in the future.
Kyrgyz President Sadyr Japarov has postponed the next presidential election by several months, fueling speculation about his intention to seek a second term. The move allows him to complete his full six-year mandate and marks a potential shift toward greater political consolidation.
A passenger boat caught fire and capsized late Tuesday on the Congo River, killing at least 50 people and leaving hundreds more missing, officials confirmed Wednesday. The tragedy occurred near the northwestern town of Mbandaka in the Democratic Republic of the Congo.
The Chinese and Vietnamese navies have launched a week-long joint patrol in the Gulf of Tonkin, a move aimed at deepening maritime cooperation between the two countries.
Finnish power grid operator Fingrid announced on Wednesday that repairs to the damaged EstLink 2 subsea power line, which connects Finland and Estonia, will begin in May, with the line expected to return to commercial use by July 15, 2025.
U.S. President Donald Trump has signed an executive order directing the Secretary of Commerce to launch an investigation into the country’s heavy reliance on imported critical minerals.
Kyrgyz President Sadyr Japarov has postponed the next presidential election by several months, fueling speculation about his intention to seek a second term. The move allows him to complete his full six-year mandate and marks a potential shift toward greater political consolidation.
Türkiye has firmly rejected Greece's unilateral actions and claims regarding maritime spatial planning (MSP) in the Aegean Sea and Eastern Mediterranean, asserting that these actions will have no legal consequences for Ankara.
A passenger boat caught fire and capsized late Tuesday on the Congo River, killing at least 50 people and leaving hundreds more missing, officials confirmed Wednesday. The tragedy occurred near the northwestern town of Mbandaka in the Democratic Republic of the Congo.
A new wave of attacks targeting French prisons has emerged overnight, with cars set on fire at several facilities, including at the Tarascon prison in southern France.
Iranian Foreign Minister Abbas Araqchi is set to visit Russia on Thursday, ahead of a second round of talks between Tehran and the United States regarding Iran's nuclear program. According to Russia’s RIA state news agency, Araqchi will meet with senior Russian officials during the visit.
A small plane crashed near Kopake, New York, on April 13, killing at 6 people. The Mitsubishi MU-2B aircraft, carrying six people, went down under unclear circumstances. This marks the second aviation accident in New York in a week, raising safety concerns.
Start your day informed with AnewZ Morning Brief: here are the top news stories for April 10th, covering the latest developments you need to know.
A quiet Thursday afternoon at St. Peter’s Basilica turned into something extraordinary, as visitors caught a rare glimpse of Pope Francis — not in his familiar white papal robes, but dressed in black trousers and a striped blanket.
In a dramatic about-face, U.S. President Donald Trump on Wednesday announced a 90-day pause on newly implemented tariffs for dozens of countries — a move that eased market turmoil but further escalated tensions with China.
Several regions in Ukraine faced heightened alert on Palm Sunday, as reports of explosions and missile threats drew public attention and official responses.
Israeli and British scientists have developed a breakthrough blood test capable of detecting Parkinson’s disease in its earliest stages—before symptoms even begin—potentially revolutionizing diagnosis and treatment.
China State Shipbuilding Corporation’s Haishen Medical Technology Co has developed the world’s first emergency medical rescue drone to enhance disaster response capabilities in extreme environments.
The European Commission is preparing to adopt emergency measures to curb the spread of bird flu in Poland’s Masovian and Greater Poland regions, where 73 outbreaks have occurred in two months. These steps aim to protect public health and the poultry industry amid growing concerns.
Kyrgyzstan has joined the TB-Free Central Asia initiative, a regional effort launched by the World Health Organization (WHO) and five Central Asian countries to eliminate tuberculosis and drug-resistant TB by 2030.
The Philippine government has imposed a temporary ban on importing both wild and domestic birds from Belgium after an outbreak of highly pathogenic avian influenza (H5N1) was confirmed in the city of Sint-Niklaas. The Department of Agriculture announced the suspension on Monday, citing the need to p
Kyrgyz President Sadyr Japarov has postponed the next presidential election by several months, fueling speculation about his intention to seek a second term. The move allows him to complete his full six-year mandate and marks a potential shift toward greater political consolidation.
Türkiye has firmly rejected Greece's unilateral actions and claims regarding maritime spatial planning (MSP) in the Aegean Sea and Eastern Mediterranean, asserting that these actions will have no legal consequences for Ankara.
A passenger boat caught fire and capsized late Tuesday on the Congo River, killing at least 50 people and leaving hundreds more missing, officials confirmed Wednesday. The tragedy occurred near the northwestern town of Mbandaka in the Democratic Republic of the Congo.
A new wave of attacks targeting French prisons has emerged overnight, with cars set on fire at several facilities, including at the Tarascon prison in southern France.
Iranian Foreign Minister Abbas Araqchi is set to visit Russia on Thursday, ahead of a second round of talks between Tehran and the United States regarding Iran's nuclear program. According to Russia’s RIA state news agency, Araqchi will meet with senior Russian officials during the visit.
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