Two U.S. service members and a U.S. civilian were killed, while three other American troops were wounded in an ambush carried out by an ISIS gunman during a joint patrol in central Syria on Saturday, according to U.S. Central Command.
The Syrian Arab News Agency (SANA), citing an unnamed security source, said the attacker was killed during the incident. No details were provided regarding the motives or circumstances of the attack.
The shooting prompted a temporary closure of the highway linking Deir ez-Zor in eastern Syria with Damascus. Following the incident, intensive aerial activity was reported over the area, with US helicopters evacuating the wounded to the Al-Tanf base in southeastern Syria.
The area is known for the presence of sleeper cells affiliated with the Islamic State (ISIS/Daesh), which continues to carry out sporadic attacks across Syria’s southeastern desert.
U.S. forces operate in Syria as part of the international coalition against ISIS, formed under U.S. leadership in 2014. Syria officially joined the coalition on 12 November 2025. The coalition has conducted military operations against ISIS in Syria and Iraq, although Damascus had not previously participated.
Since the overthrow of Bashar al-Assad’s regime in December 2024, Syria’s new administration has been working to restore security and stabilise conditions across the country.
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