One person was killed and dozens injured after two passenger trains collided near Bedford in central England on Friday, prompting a major emergency response, British Transport Police said.
British Transport Police said it was responding to an incident 60 miles north of London.
A video posted on social media showed what appeared to be the front of one train entangled with the back of another, with both still on the tracks.
The East of England Ambulance Service said it had dispatched an air ambulance and urged people to avoid the area.
Transport Minister Heidi Alexander said she was "deeply concerned" by reports of the collision in a post on X.
Bedfordshire Fire and Rescue Service said crews were at the scene of the incident just south of the town of Bedford and also called on the public to steer clear.
Train operator East Midlands Railway said it was unable to run services in or out of London for the rest of the day, while Thameslink said all lines between Luton and Bedford were blocked due to a problem under investigation.
Emergency services were called at about 5:15 p.m. (16:15 GMT) to the line south of Bedford, where two East Midlands Railway trains were involved in the crash.
A video posted on social media by one of the passengers showed what appeared to be the front of one train entangled with the back of another, with the carriages appearing to remain upright on the tracks.
"My thoughts are with the family of the person who has sadly lost their life, and with those who have been seriously injured," Prime Minister Keir Starmer said in a statement.
The East of England Ambulance Service said a large number of crews had been deployed, including more than 20 ambulances and six air ambulances.
One person died at the scene, 11 people suffered very serious injuries, 22 were seriously injured and 56 had minor injuries, it said.
Deputy Chief Constable Stuart Cundy said a significant emergency service response was under way as authorities worked to establish what had happened.
Peter Knapp, a doctor who said on social media site Bluesky he was on board one of the trains, described a "sudden crash" with one carriage off the rails and said he had sustained minor injuries.
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