Johnson & Johnson said on Thursday it will discontinue a late-stage study of an experimental E.coli vaccine it was developing in partnership with Sanofi.
The drugmaker said its decision was based on the recommendation of an independent committee that found the vaccine candidate may not be sufficiently effective compared with a placebo in preventing infections caused by a group of bacteria commonly found in the gut.
No safety signals related to the experimental vaccine were identified, J&J said, adding that it was conducting follow-ups for participants currently enrolled in the trial.
The study was testing the safety and efficacy of a single dose of the experimental shot, ExPEC9V, in preventing E.coli disease, including sepsis and blood infections.
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Israel said it had killed Alireza Tangsiri, the Commander of Iran’s Islamic Revolutionary Guards Corps (IRGC)’s Navy, on Thursday, as confict in the Middle East continued.
A drone has flown into Estonian airspace from Russia. It happened early on Wednesday morning and slammed into a chimney at a local power station, the Baltic country's Internal Security Service told public broadcaster ERR.
Iran has rejected a U.S. proposal to end the war, insisting any ceasefire will occur only on its own terms and timeline, according to a senior political-security official speaking to state-run Press TV on Wednesday.
Marine Le Pen, leader of France’s far-right National Rally (RN), said on Wednesday that the U.S. had “clearly made a mistake” in launching strikes on Iran, arguing Washington misjudged the resilience of the Iranian regime.
NASA announced on Tuesday it has cancelled plans to deploy a space station in lunar orbit and will instead use components from the project to build a $20 billion base on the moon's surface, while also planning to send a nuclear-powered spacecraft to Mars.
The UK Health Security Agency (UKHSA) said that as of Wednesday evening, it has identified six new cases of meningococcal disease in Kent, bringing the total of confirmed or suspected cases to at least 27.
The Scottish Parliament has voted against legalising assisted dying, ending a years-long campaign to make Scotland the first part of the UK to allow the practice.
The war in the Middle East is beginning to disrupt the flow of critical medicines to Gulf countries, raising concerns about the supply of cancer treatments and other temperature-sensitive drugs, according to pharmaceutical industry executives.
The World Health Organization (WHO) has released $2m in emergency funding to support health responses in Lebanon, Iraq and Syria as escalating regional conflict strains hospitals, raises displacement and increases pressure on already fragile health systems.
Measles cases across Europe and Central Asia fell sharply in 2025 compared to the previous year but health officials have warned that the risk of fresh outbreaks remains unless vaccination gaps are urgently addressed.
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