Eleven people were killed on Tuesday when dozens of vehicles crashed on both sides of a fog-covered motorway in eastern Bulgaria, Prime Minister Rumen Radev said.
The interior ministry said 50 injured people had been taken to hospital.
The pile-up happened on the A1, which links the capital, Sofia, with the Black Sea city of Burgas. Images broadcast by local media showed cars and lorries strewn across all six lanes, many of them crushed, overturned or forced off the road.
Police, firefighters and ambulance crews were sent to the scene.
Fog was the likely cause, according to Lyubomir Nikolov, secretary general of the interior ministry. He told reporters at the scene that the crash began with a collision between a bus and a lorry on the Burgas-bound carriageway.
Chief Inspector Todor Mishinev of the Yambol regional police directorate told Nova TV that some people were still trapped in their vehicles.
“Right now, the priority is rescue operations. Once they are completed, the procedural and investigative actions will be carried out,” he said.
Radev called the crash a “tragedy” in a statement issued during a visit to Bulgaria by European Commission President Ursula von der Leyen. He said he had sent aircraft to evacuate the injured and planned to visit the site.
Von der Leyen said she would end her visit early.
“I would like to express my deepest condolences and I would like to pay respects to the rescue teams,” she said.
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