Beijing, February 24, 2025 – A newly identified bat coronavirus, designated HKU5-CoV-2, has been found to enter human cells using the same cell-surface protein as SARS-CoV-2, the virus responsible for COVID-19, according to a study published in the journal Cell.
While the virus possesses key features such as a furin cleavage site that facilitates entry via the ACE2 receptor, researchers noted that it does not infect human cells as efficiently as SARS-CoV-2.
In laboratory experiments, HKU5-CoV-2 successfully infected human cells with high ACE2 levels in both test tube assays and in models simulating human intestinal and airway tissues. The study further identified several monoclonal antibodies and antiviral drugs capable of targeting the bat virus, offering potential avenues for preemptive therapeutic strategies.
The research has attracted significant market attention; Bloomberg reported that news of the study influenced a modest rise in shares of several COVID vaccine manufacturers, including Pfizer, Moderna, and Novavax. However, infectious disease expert Dr. Michael Osterholm from the University of Minnesota cautioned that the reaction might be “overblown.” He pointed to the extensive preexisting immunity in the global population against similar SARS viruses and the markedly lower binding affinity of HKU5-CoV-2 to human ACE2 compared with SARS-CoV-2, factors that could mitigate the pandemic risk.
While the discovery highlights a potential pathway for zoonotic spillover, the authors of the study stressed that several suboptimal factors for human adaptation suggest that the risk of this bat virus emerging as a human pathogen should not be exaggerated. The findings add to the growing body of research on coronaviruses and underscore the importance of continued surveillance of wildlife pathogens.
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Indonesia is pressing for a “fair and square” trade deal with Washington, senior ministers said, as Jakarta hustles to head off a 32 % U.S. tariff by offering to boost American imports by up to $19 billion while safeguarding its own economic interests.
Brazil's Supreme Court has ordered the arrest of former President Fernando Collor de Mello after rejecting his appeals against a corruption conviction, with a ruling from 2023 sentencing him to nearly nine years in prison for money laundering and bribery.
The U.S. military said a missile explosion that killed at least a dozen people near a UNESCO site in Yemen's capital, Sanaa, was caused by a Houthi-fired weapon, not an American airstrike, countering local claims and intensifying scrutiny over the rising civilian toll in the conflict.
The United States is set to host an energy summit in Alaska in early June, where President Donald Trump’s administration hopes Japan and South Korea will commit to the $44 billion Alaska LNG project, a major energy initiative aimed at expanding U.S. gas exports to Asia.
A large-scale missile and drone strike hit Kyiv overnight, killing at least 12 people in what Ukrainian officials called the most significant attack on the capital this year, as diplomatic efforts to reach a resolution continue.
Indonesia is pressing for a “fair and square” trade deal with Washington, senior ministers said, as Jakarta hustles to head off a 32 % U.S. tariff by offering to boost American imports by up to $19 billion while safeguarding its own economic interests.
Brazil's Supreme Court has ordered the arrest of former President Fernando Collor de Mello after rejecting his appeals against a corruption conviction, with a ruling from 2023 sentencing him to nearly nine years in prison for money laundering and bribery.
The U.S. military said a missile explosion that killed at least a dozen people near a UNESCO site in Yemen's capital, Sanaa, was caused by a Houthi-fired weapon, not an American airstrike, countering local claims and intensifying scrutiny over the rising civilian toll in the conflict.
The United States is set to host an energy summit in Alaska in early June, where President Donald Trump’s administration hopes Japan and South Korea will commit to the $44 billion Alaska LNG project, a major energy initiative aimed at expanding U.S. gas exports to Asia.
A large-scale missile and drone strike hit Kyiv overnight, killing at least 12 people in what Ukrainian officials called the most significant attack on the capital this year, as diplomatic efforts to reach a resolution continue.
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