Beijing, February 24, 2025 – A newly identified bat coronavirus, designated HKU5-CoV-2, has been found to enter human cells using the same cell-surface protein as SARS-CoV-2, the virus responsible for COVID-19, according to a study published in the journal Cell.
While the virus possesses key features such as a furin cleavage site that facilitates entry via the ACE2 receptor, researchers noted that it does not infect human cells as efficiently as SARS-CoV-2.
In laboratory experiments, HKU5-CoV-2 successfully infected human cells with high ACE2 levels in both test tube assays and in models simulating human intestinal and airway tissues. The study further identified several monoclonal antibodies and antiviral drugs capable of targeting the bat virus, offering potential avenues for preemptive therapeutic strategies.
The research has attracted significant market attention; Bloomberg reported that news of the study influenced a modest rise in shares of several COVID vaccine manufacturers, including Pfizer, Moderna, and Novavax. However, infectious disease expert Dr. Michael Osterholm from the University of Minnesota cautioned that the reaction might be “overblown.” He pointed to the extensive preexisting immunity in the global population against similar SARS viruses and the markedly lower binding affinity of HKU5-CoV-2 to human ACE2 compared with SARS-CoV-2, factors that could mitigate the pandemic risk.
While the discovery highlights a potential pathway for zoonotic spillover, the authors of the study stressed that several suboptimal factors for human adaptation suggest that the risk of this bat virus emerging as a human pathogen should not be exaggerated. The findings add to the growing body of research on coronaviruses and underscore the importance of continued surveillance of wildlife pathogens.
Measles cases in the European region surged to a 25-year high in 2024, more than doubling from the previous year, the World Health Organisation (WHO) and UNICEF reported on Thursday, urging immediate action to restore vaccination levels that declined after the COVID-19 pandemic.
BioNTech forecasts a revenue decline for 2025, expecting between 1.7 billion and 2.2 billion euros, down from 2.75 billion euros last year. This drop is due to Pfizer write-downs and stable vaccination rates. BioNTech also plans significant job cuts and new hires.
The World Health Organization's Director-General, Tedros Adhanom Ghebreyesus, has expressed confidence that a global pandemic agreement will be finalized by May 2025, despite concerns over US participation under President-elect Donald Trump.
The Italian government has lifted fines imposed on those who refused mandatory COVID-19 vaccinations, a move that follows criticism over the previous administration's pandemic response and the ongoing challenge of curbing the virus's spread in the country.
Start your day informed with AnewZ Morning Brief: here are the top news stories for March 19th, covering the latest developments you need to know.
South Korean police will deploy 14,000 officers in Seoul on the day of President Yoon Suk Yeol’s impeachment ruling, anticipating protests and security threats. The Constitutional Court is set to deliver its verdict soon, with heightened measures in place.
China and Kazakhstan have agreed to deepen cooperation in key areas, including trade, security, and Belt and Road projects. At a high-level meeting in Beijing, officials emphasised stronger political ties, economic collaboration, and cultural exchanges to advance their strategic partnership.
NASA astronauts Butch Wilmore and Suni Williams completed an unexpectedly long 286-day mission on the ISS, returning to Earth aboard a SpaceX capsule after delays caused by technical issues with Boeing’s Starliner.
British Prime Minister Keir Starmer spoke with Ukrainian President Volodymyr Zelenskyy on Tuesday to discuss the progress made by U.S. President Donald Trump in ceasefire talks with Russia, with both leaders emphasising the importance of a just and lasting peace in Ukraine.
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Regarding the Armenia-Azerbaijan process, we cannot forget the years of occupation, and we will not forget them, President Ilham Aliyev said in his speech at the opening ceremony of the 12th Global Baku Forum.
President Donald Trump has vowed to respond to the European Union's counter-tariffs, escalating tensions over the U.S. steel and aluminum duties that have sparked a trade dispute between the two economic powers.
Russian President Vladimir Putin agreed on Tuesday to a proposal by U.S. President Donald Trump that Russia and Ukraine cease attacking each other's energy infrastructure for 30 days, the Kremlin said following a lengthy phone discussion between the leaders.
Start your day informed with AnewZ Morning Brief: here are the top news stories for March 19th, covering the latest developments you need to know.
South Korean police will deploy 14,000 officers in Seoul on the day of President Yoon Suk Yeol’s impeachment ruling, anticipating protests and security threats. The Constitutional Court is set to deliver its verdict soon, with heightened measures in place.
British Prime Minister Keir Starmer spoke with Ukrainian President Volodymyr Zelenskyy on Tuesday to discuss the progress made by U.S. President Donald Trump in ceasefire talks with Russia, with both leaders emphasising the importance of a just and lasting peace in Ukraine.
Fresh hostilities erupted in the Russia-Ukraine conflict on Wednesday, with reported air strikes causing infrastructure damage and evacuations despite a recently agreed partial ceasefire.
Putin has paused energy facility strikes, but a full ceasefire remains elusive. The move signals ongoing tensions, with discussions about a wider peace deal set to begin, leaving questions about Ukraine’s role in the negotiations.
Start your day informed with AnewZ Morning Brief: here are the top news stories for March 19th, covering the latest developments you need to know.
South Korean police will deploy 14,000 officers in Seoul on the day of President Yoon Suk Yeol’s impeachment ruling, anticipating protests and security threats. The Constitutional Court is set to deliver its verdict soon, with heightened measures in place.
China and Kazakhstan have agreed to deepen cooperation in key areas, including trade, security, and Belt and Road projects. At a high-level meeting in Beijing, officials emphasised stronger political ties, economic collaboration, and cultural exchanges to advance their strategic partnership.
NASA astronauts Butch Wilmore and Suni Williams completed an unexpectedly long 286-day mission on the ISS, returning to Earth aboard a SpaceX capsule after delays caused by technical issues with Boeing’s Starliner.
British Prime Minister Keir Starmer spoke with Ukrainian President Volodymyr Zelenskyy on Tuesday to discuss the progress made by U.S. President Donald Trump in ceasefire talks with Russia, with both leaders emphasising the importance of a just and lasting peace in Ukraine.
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