Iran’s supreme leader dismissed a key U.S. demand to halt uranium enrichment but did not close the door on further negotiations, as nuclear talks continue amid rising regional tensions.

Ayatollah Ali Khamenei on Wednesday criticised a U.S.-backed nuclear proposal, rejecting the idea of ending uranium enrichment, which he called vital to Iran’s sovereignty and energy needs. He described the proposal as contrary to Iran’s principle of self-reliance.

“If we do not have enrichment, then we should extend our hand (begging) to the U.S.,” Khamenei said, reiterating that enrichment is central to Iran’s peaceful nuclear ambitions.

Despite the sharp rhetoric, Khamenei did not rule out further dialogue. Iran’s Foreign Minister Abbas Araghchi confirmed Tehran will issue a formal response soon. Talks are seen as crucial for easing sanctions that have hit Iran’s economy.

Details of the U.S. proposal remain unclear. Reports suggest it includes a nuclear consortium to handle enrichment for Iran and its neighbours, with possible limited enrichment rights for Iran.

President Donald Trump has reinstated his “maximum pressure” campaign, renewing sanctions and warning of military action. Khamenei accused U.S. leaders of seeking to dismantle Iran’s nuclear industry, but his remarks stopped short of ending negotiations.

Experts warn that failure to reach a deal could escalate tensions further, risking conflict and ending cooperation with international nuclear inspectors.

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