Azerbaijan women's basketball team clinch historic win in European cup final
The Azerbaijani women’s 3x basketball team clinched the silver medal at the European Cup to make history at the just concluded tournament in Copenha...
Scientists in Sydney have identified how inactivation of a stress-response pathway enables estrogen receptor-positive breast cancer cells to resist treatment, a finding that could help doctors predict therapy outcomes and tailor treatment.
Researchers at the Garvan Institute of Medical Research in Australia have pinpointed a mechanism that explains why some estrogen receptor-positive (ER+) breast cancers fail to respond to standard therapies. ER+ is the most common breast cancer subtype globally.
The study, published in Italy’s Journal of Experimental & Clinical Cancer Research, showed that shutting down the JNK pathway allows cancer cells to evade treatment. Normally, the JNK pathway functions as a cellular alarm, halting cell division or triggering self-destruction when cells are damaged, including during cancer therapy.
“When we knocked out genes involved in the JNK pathway, cancer cells continued to grow despite treatment,” said first author Sarah Alexandrou from the Garvan Institute and the University of New South Wales (UNSW). “These cells also spread to form more metastases in preclinical models.”
The resistance was observed not only in lab experiments but also in patient tumour samples. In those cases, low JNK activity was linked to poor treatment responses.
Associate Professor Liz Caldon, co-author from the Garvan Institute and UNSW, said the discovery could reshape treatment strategies. She noted that testing patients for JNK pathway activity could help identify those unlikely to benefit from current first-line therapies such as endocrine treatment combined with CDK4/6 inhibitors.
The findings may pave the way for more personalised therapies, potentially improving outcomes for thousands of patients diagnosed with ER+ breast cancer each year.
AnewZ has learned that India has once again blocked Azerbaijan’s application for full membership in the Shanghai Cooperation Organisation, while Pakistan’s recent decision to consider diplomatic relations with Armenia has been coordinated with Baku as part of Azerbaijan’s peace agenda.
A powerful eruption at Japan’s Shinmoedake volcano sent an ash plume more than 3,000 metres high on Sunday morning, prompting safety warnings from authorities.
A day of mourning has been declared in Portugal to pay respect to victims who lost their lives in the Lisbon Funicular crash which happened on Wednesday evening.
The UK is gearing up for Exercise Pegasus 2025, its largest pandemic readiness test since COVID-19. Running from September to November, this full-scale simulation will challenge the country's response to a fast-moving respiratory outbreak.
A Polish Air Force pilot was killed on Thursday when an F-16 fighter jet crashed during a training flight ahead of the 2025 Radom International Air Show.
The World Health Organization has added GLP-1 drugs to treat diabetes to its essential medicines list, alongside treatments for cystic fibrosis and cancer, and said it hopes this will improve global access to the costly drugs.
Zambia has formalised a strategic partnership with the International Vaccine Institute (IVI) to bolster domestic vaccine manufacturing capacity, the Zambia National Public Health Institute (ZNPHI) announced on Friday.
Four-time Tour de France winner Chris Froome was airlifted to hospital in Toulon after suffering a training crash which left him with broken ribs, a collapsed lung and a back fracture, his team Israel-Premier Tech said on Thursday (August 28).
Bulgaria reported outbreaks of highly pathogenic avian influenza on three farms in the southern part of the country, the World Organisation for Animal Health (WOAH) said on Monday, as Europe faces a seasonal upturn in the deadly disease.
Africa has unveiled a continental emergency preparedness and response plan to tackle cholera from September 2025 to February 2026.
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