Baku Climate Action Week Commences, Convening National and Global Actors to Build on Legacy of COP29
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Scientists in Sydney have identified how inactivation of a stress-response pathway enables estrogen receptor-positive breast cancer cells to resist treatment, a finding that could help doctors predict therapy outcomes and tailor treatment.
Researchers at the Garvan Institute of Medical Research in Australia have pinpointed a mechanism that explains why some estrogen receptor-positive (ER+) breast cancers fail to respond to standard therapies. ER+ is the most common breast cancer subtype globally.
The study, published in Italy’s Journal of Experimental & Clinical Cancer Research, showed that shutting down the JNK pathway allows cancer cells to evade treatment. Normally, the JNK pathway functions as a cellular alarm, halting cell division or triggering self-destruction when cells are damaged, including during cancer therapy.
“When we knocked out genes involved in the JNK pathway, cancer cells continued to grow despite treatment,” said first author Sarah Alexandrou from the Garvan Institute and the University of New South Wales (UNSW). “These cells also spread to form more metastases in preclinical models.”
The resistance was observed not only in lab experiments but also in patient tumour samples. In those cases, low JNK activity was linked to poor treatment responses.
Associate Professor Liz Caldon, co-author from the Garvan Institute and UNSW, said the discovery could reshape treatment strategies. She noted that testing patients for JNK pathway activity could help identify those unlikely to benefit from current first-line therapies such as endocrine treatment combined with CDK4/6 inhibitors.
The findings may pave the way for more personalised therapies, potentially improving outcomes for thousands of patients diagnosed with ER+ breast cancer each year.
AnewZ has learned that India has once again blocked Azerbaijan’s application for full membership in the Shanghai Cooperation Organisation, while Pakistan’s recent decision to consider diplomatic relations with Armenia has been coordinated with Baku as part of Azerbaijan’s peace agenda.
A day of mourning has been declared in Portugal to pay respect to victims who lost their lives in the Lisbon Funicular crash which happened on Wednesday evening.
Video from the USGS (United States Geological Survey) showed on Friday (19 September) the Kilauea volcano in Hawaii erupting and spewing lava.
At least eight people have died and more than 90 others were injured following a catastrophic gas tanker explosion on a major highway in Mexico City’s Iztapalapa district on Wednesday, authorities confirmed.
A powerful 7.4-magnitude earthquake struck off Russia’s Kamchatka Peninsula on 13 September with no tsunami threat, coming just weeks after the region endured a devastating 8.8-magnitude quake — the strongest since 1952.
U.S. President Donald Trump’s decision to impose 100% tariffs on branded and patented pharmaceuticals manufactured abroad poses a serious threat to Germany’s pharmaceutical sector, according to the Berlin-based industry group Verband Forschender Arzneimittelhersteller (vfa).
A flock of Canadian ostriches set to be culled, after two dead birds tested positive for avian flu, has been granted a last-minute stay of execution from Canada's highest court - for now.
The Trump administration's plan to dramatically raise fees for H-1B visas is drawing concern from U.S. healthcare groups who say the move could worsen staffing shortages as more than half of healthcare workers consider changing jobs within the next year.
Australian authorities have reaffirmed that paracetamol is safe for pregnant women, rejecting U.S. claims that it raises the risk of autism in babies.
The United Nations agency focusing on the HIV/AIDS pandemic could close by the end of next year as the U.N. restructures in the face of a funding crisis, according to a U.N. document published online
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