Two dead, eight injured in San Diego plane crash- officials
A tragic plane crash early Thursday morning shook a quiet residential neighborhood in San Diego, California. According to officials, there are two dead, eight injured.
Scientists in the UK have developed a super-strong antibody that could dramatically improve how the immune system attacks cancer cells by boosting its activation power.
Researchers at the University of Southampton have designed a new type of antibody that could strengthen the immune system’s ability to fight cancer. The team, supported by Cancer Research UK, discovered that by increasing the rigidity of antibodies - tiny proteins produced by white blood cells - they could trigger a much stronger immune response.
Antibodies work by attaching to harmful cells like bacteria, viruses, or cancer cells, marking them for attack by the immune system. The new prototype, which features extra structural bonds to stiffen its Y-shaped form, was found to outperform naturally occurring antibodies in lab tests.
“The concept of using immuno-stimulation for cancer treatment is very exciting,” said Professor Mark Cragg of the Centre for Cancer Immunology. “Even small increases in rigidity significantly improve how well antibodies can activate the immune system.”
Using supercomputers, the team visualized antibodies at atomic detail to precisely insert additional disulfide bonds—tiny bridges that stabilize the structure. This made the antibodies more rigid, allowing them to hold immune receptors closer together and produce a stronger activation signal.
PhD student Isabel Elliott explained: “Floppier antibodies are less effective at triggering immune cells. Rigid ones seem to organize the receptors better, leading to a more powerful response.”
Dr. Ivo Tews, Professor in Structural Biology, added that this strategy could be applied to a wide range of immune-related molecules, not just those used in cancer therapy.
Dr. Iain Foulkes, Executive Director of Research and Innovation at Cancer Research UK, emphasized the potential impact of the findings: “Refining how we harness the immune system is a vital step forward. These super-strong antibodies could empower new, more effective treatments for patients undergoing immunotherapy.”
The research is published in the journal Nature Communications, marking a promising step toward next-generation cancer treatments designed to supercharge the body’s natural defenses.
Tensions flare in the India-France Rafale deal as France refuses to share the fighter jet’s source code, limiting India’s ability to integrate indigenous weapons and reducing its combat autonomy.
France has rejected India’s request to share source codes needed to integrate indigenous weapons into Rafale fighter jets. Despite repeated appeals, French manufacturer Dassault Aviation has refused to compromise on the issue
Anton Kobyakov, adviser to Russian President Vladimir Putin, claimed at the St. Petersburg International Legal Forum that the USSR’s dissolution was legally invalid and that the Soviet Union still exists under constitutional law, framing the Ukraine war as an “internal process.”
AnewZ and Kazakhstan’s Jibek Joly/Silk Way TV channel co-hosted a special AnewZ Talks in Astana at Maqsut Narikbayev University (MNU), uniting global experts and young leaders at Silk Road Media Group’s journalism school to explore the growing intersection of media and diplomacy.
The Tehran Dialogue Forum 2025, scheduled for May 18–19, will host 200 international guests, including 40 current and former European officials.
At its inaugural developer conference on Thursday, Anthropic unveiled two new AI models, Claude Opus 4 and Claude Sonnet 4, part of its next-generation Claude 4 family.
Cryptocurrency exchange Coinbase has confirmed that at least 69,461 customers had personal and financial information stolen in a months-long data breach, which the company disclosed last week.
Taiwan's Computex tech show brought together thousands of international participants on Tuesday, showcasing the highly advanced Artificial Intelligence and robotic systems.
Microsoft announced on Monday that it will begin hosting AI models from Elon Musk's xAI, Meta Platforms, and European startups like Mistral and Black Forest Labs in its own data centers.
Xiaomi CEO Lei Jun announced a $6.9 billion investment plan over the next decade to develop advanced chips, unveiling the new Xring O1 system-on-chip this Thursday, aiming to boost the company’s high-end smartphone strategy and reduce reliance on Qualcomm.
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