Rybelsus, an oral form of the GLP-1 drug semaglutide, has been discovered to provide similar cardiovascular benefits as the injectable forms of the drug.
Researchers presented this at the American College of Cardiology scientific meeting held in Chicago in March.
In a trial of 9,650 patients with type 2 diabetes, who had clogged heart arteries and/or chronic kidney disease, those taking Rybelsus were overall 14% less likely to experience heart-related death, heart attack or stroke than those who received a placebo after an average follow-up of four years.
Semaglutide, a glucagon-like peptide-1 receptor agonist, has been shown to reduce the risk of adverse cardiovascular events in patients with diabetes according to the New England Journal of Medicine.
The researchers saw a 26% reduction in non-fatal heart attacks with oral semaglutide and a 12% reduction in non-fatal strokes, both of which “are among the most common and devastating complications of diabetes,” study co author Dr. John Buse of the University of North Carolina School of Medicine said in a statement.
It is still unclear though the exact mechanism through which the drugs reduce cardiovascular risk is not known, however, their anti-inflammatory activity is thought to play a role.
“Semaglutide has been a mainstay of our efforts to reduce heart attack and stroke in people with diabetes,” Buse said. “Having an oral option to deliver this highly effective therapy is a big advance.”
Despite the resounding success of the drug manufactured alongside Ozempic, the injectable form by Pharma giant Novo Nordisk, the most common side effects mainly gastrointestinal problems such as nausea, diarrhea, constipation and gas remain.
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The Bulgarian government, headed by Rosen Zhelyazkov, overcame a no-confidence vote initiated over its foreign policy.
Iran and Afghanistan are working to strengthen diplomatic and economic ties as the Taliban seeks greater engagement with the United States. The discussions focus on trade, security, and regional stability, highlighting shifting alliances in the region amid ongoing geopolitical tensions.
Asian stock markets experienced a significant decline on Thursday following the announcement by US President Donald Trump of new reciprocal tariffs on several US trade partners. The tariffs, which range from 10% to 50%, were announced by Trump on April 2, a day he referred to as “Liberation Day.”
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The Armenian armed forces attempted three reconnaissance drone flights over Azerbaijan Army positions near Gerenzur, but all were successfully intercepted. Meanwhile, Armenian units repeatedly fired on Azerbaijani positions from multiple regions, escalating tensions in the area.
Apple marked its 49th anniversary by reaching a market capitalization of $3.3 trillion. Despite recent tech stock volatility, Apple's shares surged 28% in 2024.
The 19th MedExpo Kyrgyzstan 2025 has opened in Bishkek, featuring over 50 companies from 11 countries. The event serves as a key platform for medical advancements, presenting cutting-edge solutions in healthcare, pharmaceuticals, and medical technology. The exhibition runs until April 3.
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From 1 June 2025, it will be illegal for businesses in the United Kingdom to sell or supply all single-use or "disposable" vapes. Only reusable vapes are allowed for sale.
A global survey by AXA and IPSOS reveals that workplace stress, anxiety, and burnout are worsening, with financial instability, job insecurity, and constant exposure to negative news among the key factors affecting mental well-being
A Chinese medical team has successfully transplanted a gene-edited pig liver into a brain-dead human, marking a breakthrough in xenotransplantation. The organ functioned normally, showing no signs of acute rejection or viral transmission during a 10-day observation period.
The Bulgarian government, headed by Rosen Zhelyazkov, overcame a no-confidence vote initiated over its foreign policy.
Iran and Afghanistan are working to strengthen diplomatic and economic ties as the Taliban seeks greater engagement with the United States. The discussions focus on trade, security, and regional stability, highlighting shifting alliances in the region amid ongoing geopolitical tensions.
Asian stock markets experienced a significant decline on Thursday following the announcement by US President Donald Trump of new reciprocal tariffs on several US trade partners. The tariffs, which range from 10% to 50%, were announced by Trump on April 2, a day he referred to as “Liberation Day.”
The inaugural Samarkand International Climate Forum will kick off on 4th April at the Silk Road Samarkand Congress Center in Uzbekistan. The high-profile forum will be held under the theme "Central Asia Facing Global Climate Challenges: Consolidation for Shared Prosperity."
TikTok’s fate in the United States is once again hanging in the balance, as a looming deadline threatens to force a sale—or trigger a nationwide ban—amid a flurry of last-minute bids and high-stakes political maneuvering.
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