AstraZeneca’s new weight-loss pill, AZD5004, shows promise in early trials with tolerable side effects, advancing to Phase II studies focused on reducing obesity.
AstraZeneca reported on Monday that its experimental weight-loss pill, AZD5004, licensed from China's Eccogene for up to $2 billion, was found safe and tolerable in an early-stage trial.
The study, which included 72 participants who were either healthy or had type 2 diabetes, showed side effects consistent with other GLP-1 drugs, such as nausea and vomiting. Based on these findings, AstraZeneca has advanced AZD5004 to Phase II trials focused on weight reduction in overweight and obese individuals, with completion expected by late 2025.
Unlike injectable treatments from competitors Eli Lilly and Novo Nordisk, AZD5004 is a small molecule pill that can be combined with other medications and taken with or without food, offering potential advantages for patients with additional health conditions.
AstraZeneca also shared early-stage data on other obesity drugs, AZD6234 and AZD9550, which target different hunger-related hormones and will undergo further Phase II testing through 2026.
Meanwhile, Viking Therapeutics released early trial results for its own oral obesity drug, which briefly boosted its stock before a decline.
Start your day informed with AnewZ Morning Briefing: here are the top news stories for January 18th, covering the latest developments you need to know.
Russia and Iran have agreed to intensify cooperation in developing international transport corridors, especially the North-South corridor. The move aims to improve trade flows and create smoother transportation conditions for goods traveling through both countries.
The Houthis, ruling northern Yemen, have claimed responsibility for the seventh drone attack on the US aircraft carrier USS Harry Truman since its arrival in the Red Sea. The group also warned it is monitoring developments in the Gaza Strip.
Azerbaijan's commercial gas production saw a growth of over 6%, highlighting a significant boost in the country's energy sector. This increase contributes to strengthening Azerbaijan’s role as a key player in regional and global energy markets
Azerbaijan has begun the trial of Ruben Vardanyan, a billionaire and former so-called Nagorno-Karabakh official, detained in September 2023 after Azerbaijan’s takeover of the region. He denies wrongdoing and claims his interrogation protocols were falsified.
Start your day informed with AnewZ Morning Briefing: here are the top news stories for January 18th, covering the latest developments you need to know.
U.S. Congressional Azerbaijan Caucus co-chairs honour the 35th anniversary of January 20, reflecting on its impact as a pivotal moment in Azerbaijan's fight for independence.
Thousands in Belgrade held a silent protest outside RTS, honouring victims of a roof collapse. University students demanded justice for the tragedy, blaming Serbian authorities.
South Korea's impeached president Yoon Suk Yeol appeared in court to contest his detention extension on insurrection charges tied to his martial law declaration.
Reports of a two-month halt in Azerbaijani gas supplies to Serbia are false. Despite a technical issue at Shah Deniz Alpha, Shah Deniz Bravo ensures steady exports, with supplies set to resume soon. BP confirms no damage or environmental impact.
Coast Guard divers Chuck Fox and Corey Smith from the US Cutter *Polar Star* successfully repaired a leaking shaft in the freezing waters of McMurdo Sound, Antarctica.
Azerbaijan has temporarily halted its contracted natural gas supply to Bulgaria following a technical issue at BP's Alpha platform in the Shah Deniz gas field.
As we welcome the new year, it’s time to focus on species needing urgent conservation in 2025. From delicate lizards to mighty hornbills and massive sharks, all face the threat of extinction.
Over 100 Paris 2024 Olympic medals were returned due to quality issues linked to EU regulations and an untested varnish formula. The IOC has pledged to replace all defective medals.
Counterfeit alcohol poisoning in Istanbul has claimed 19 lives in 72 hours, hospitalizing 65, including 26 foreigners. Authorities closed 63 illegal vendors as the crackdown on toxic methyl alcohol continues.
An outbreak of suspected Marburg disease in Tanzania has claimed eight lives, with nine cases reported in the Kagera region, according to the World Health Organization. The high-fatality virus, spread through close contact, poses a regional risk as surveillance efforts continue.
Sri Lanka reported nearly 50,000 dengue cases in 2024, with 24 fatalities and a case fatality rate of 0.05%. The Western Province accounted for 44.1% of cases. In January 2025 alone, 2,045 cases have already been recorded, highlighting ongoing public health challenges.
The World Health Organization (WHO) has confirmed that the risk to the general population from H5N1 bird flu remains low, despite the first reported death from the virus in the United States.
Start your day informed with AnewZ Morning Briefing: here are the top news stories for January 18th, covering the latest developments you need to know.
U.S. Congressional Azerbaijan Caucus co-chairs honour the 35th anniversary of January 20, reflecting on its impact as a pivotal moment in Azerbaijan's fight for independence.
Thousands in Belgrade held a silent protest outside RTS, honouring victims of a roof collapse. University students demanded justice for the tragedy, blaming Serbian authorities.
South Korea's impeached president Yoon Suk Yeol appeared in court to contest his detention extension on insurrection charges tied to his martial law declaration.
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