AstraZeneca’s new weight-loss pill, AZD5004, shows promise in early trials with tolerable side effects, advancing to Phase II studies focused on reducing obesity.
AstraZeneca reported on Monday that its experimental weight-loss pill, AZD5004, licensed from China's Eccogene for up to $2 billion, was found safe and tolerable in an early-stage trial.
The study, which included 72 participants who were either healthy or had type 2 diabetes, showed side effects consistent with other GLP-1 drugs, such as nausea and vomiting. Based on these findings, AstraZeneca has advanced AZD5004 to Phase II trials focused on weight reduction in overweight and obese individuals, with completion expected by late 2025.
Unlike injectable treatments from competitors Eli Lilly and Novo Nordisk, AZD5004 is a small molecule pill that can be combined with other medications and taken with or without food, offering potential advantages for patients with additional health conditions.
AstraZeneca also shared early-stage data on other obesity drugs, AZD6234 and AZD9550, which target different hunger-related hormones and will undergo further Phase II testing through 2026.
Meanwhile, Viking Therapeutics released early trial results for its own oral obesity drug, which briefly boosted its stock before a decline.
The White House confirmed on Tuesday that President Donald Trump will impose a new wave of tariffs on Wednesday, escalating fears of a deepening global trade war. The announcement, set for 4 p.m. ET in the Rose Garden, marks the culmination of weeks of warnings and speculation.
Australian Prime Minister Anthony Albanese and opposition leader Peter Dutton have both pledged to defend the country’s national interests as the United States signals possible tariffs targeting Australian beef exports.
A senior Russian official is expected to arrive in Washington this week for direct talks with the Trump administration, a source familiar with the plan confirmed.
From Wednesday, European visitors to Britain will need to purchase an Electronic Travel Authorisation (ETA) before arriving, as the UK implements new pre-entry screening measures to tighten border controls.
U.S. Defense Secretary Pete Hegseth has ordered the deployment of additional warplanes to reinforce American naval assets in the Middle East, the Pentagon confirmed on Tuesday. The move follows a renewed bombing campaign in Yemen and rising friction with Iran.
Aid groups in Myanmar’s worst-hit areas urgently need shelter, food, and water after a devastating 7.7 magnitude earthquake killed over 2,700 people. Rescue efforts face challenges due to ongoing civil war, damaged infrastructure, and restricted aid access, with the toll expected to rise.
Russian forces carried out a drone attack on Ukraine’s second-largest city, Kharkiv, late Wednesday, injuring at least twenty one people and causing structural damage, according to Ukrainian officials.
French far-right leader Marine Le Pen was banned from running for public office for five years after being convicted of embezzlement, ruling her out of the 2027 presidential race. She received a four-year prison sentence, with two years suspended, and a €100,000 fine. Le Pen plans to appeal.
Apple marked its 49th anniversary by reaching a market capitalization of $3.3 trillion. Despite recent tech stock volatility, Apple's shares surged 28% in 2024.
The Armenian armed forces attempted three reconnaissance drone flights over Azerbaijan Army positions near Gerenzur, but all were successfully intercepted. Meanwhile, Armenian units repeatedly fired on Azerbaijani positions from multiple regions, escalating tensions in the area.
From 1 June 2025, it will be illegal for businesses in the United Kingdom to sell or supply all single-use or "disposable" vapes. Only reusable vapes are allowed for sale.
A global survey by AXA and IPSOS reveals that workplace stress, anxiety, and burnout are worsening, with financial instability, job insecurity, and constant exposure to negative news among the key factors affecting mental well-being
A Chinese medical team has successfully transplanted a gene-edited pig liver into a brain-dead human, marking a breakthrough in xenotransplantation. The organ functioned normally, showing no signs of acute rejection or viral transmission during a 10-day observation period.
Slovakia has declared an emergency situation following the discovery of foot-and-mouth disease on three farms in the southern part of the country, the government announced on Tuesday.
AstraZeneca, opens new tab said it will spend $2.5 billion on a research and development hub in Beijing, as the drugmaker scrambles to revive business in its second-biggest market after scandals including the arrest of its China president last year.
The White House confirmed on Tuesday that President Donald Trump will impose a new wave of tariffs on Wednesday, escalating fears of a deepening global trade war. The announcement, set for 4 p.m. ET in the Rose Garden, marks the culmination of weeks of warnings and speculation.
Australian Prime Minister Anthony Albanese and opposition leader Peter Dutton have both pledged to defend the country’s national interests as the United States signals possible tariffs targeting Australian beef exports.
A senior Russian official is expected to arrive in Washington this week for direct talks with the Trump administration, a source familiar with the plan confirmed.
From Wednesday, European visitors to Britain will need to purchase an Electronic Travel Authorisation (ETA) before arriving, as the UK implements new pre-entry screening measures to tighten border controls.
U.S. Defense Secretary Pete Hegseth has ordered the deployment of additional warplanes to reinforce American naval assets in the Middle East, the Pentagon confirmed on Tuesday. The move follows a renewed bombing campaign in Yemen and rising friction with Iran.
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