AstraZeneca’s new weight-loss pill, AZD5004, shows promise in early trials with tolerable side effects, advancing to Phase II studies focused on reducing obesity.
AstraZeneca reported on Monday that its experimental weight-loss pill, AZD5004, licensed from China's Eccogene for up to $2 billion, was found safe and tolerable in an early-stage trial.
The study, which included 72 participants who were either healthy or had type 2 diabetes, showed side effects consistent with other GLP-1 drugs, such as nausea and vomiting. Based on these findings, AstraZeneca has advanced AZD5004 to Phase II trials focused on weight reduction in overweight and obese individuals, with completion expected by late 2025.
Unlike injectable treatments from competitors Eli Lilly and Novo Nordisk, AZD5004 is a small molecule pill that can be combined with other medications and taken with or without food, offering potential advantages for patients with additional health conditions.
AstraZeneca also shared early-stage data on other obesity drugs, AZD6234 and AZD9550, which target different hunger-related hormones and will undergo further Phase II testing through 2026.
Meanwhile, Viking Therapeutics released early trial results for its own oral obesity drug, which briefly boosted its stock before a decline.
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Iran and the U.S. are set for a third round of indirect talks in Muscat, focusing on sanctions relief and guarantees over Iran’s nuclear program.
Donald Trump said talks between his envoy and Vladimir Putin made major progress toward ending the Ukraine war, urging Kyiv and Moscow to meet face-to-face.
Estonia has passed a €2.8 billion defense funding bill, raising military spending to over 5% of GDP amid growing security concerns over Russia.
George Santos, a former U.S. congressman, has been sentenced to over seven years in prison after being convicted of fraud and identity theft.
The World Food Programme has warned that its food supplies in Gaza have run out, leaving hundreds of thousands at risk as charity kitchens face imminent shutdown.
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