AstraZeneca’s new weight-loss pill, AZD5004, shows promise in early trials with tolerable side effects, advancing to Phase II studies focused on reducing obesity.
AstraZeneca reported on Monday that its experimental weight-loss pill, AZD5004, licensed from China's Eccogene for up to $2 billion, was found safe and tolerable in an early-stage trial.
The study, which included 72 participants who were either healthy or had type 2 diabetes, showed side effects consistent with other GLP-1 drugs, such as nausea and vomiting. Based on these findings, AstraZeneca has advanced AZD5004 to Phase II trials focused on weight reduction in overweight and obese individuals, with completion expected by late 2025.
Unlike injectable treatments from competitors Eli Lilly and Novo Nordisk, AZD5004 is a small molecule pill that can be combined with other medications and taken with or without food, offering potential advantages for patients with additional health conditions.
AstraZeneca also shared early-stage data on other obesity drugs, AZD6234 and AZD9550, which target different hunger-related hormones and will undergo further Phase II testing through 2026.
Meanwhile, Viking Therapeutics released early trial results for its own oral obesity drug, which briefly boosted its stock before a decline.
BERLIN, Feb 22 (Reuters) - NATO is planning to build a pipeline system from Germany to Poland and the Czech Republic to ensure a rapid supply of jet fuel for fighter aircraft in the event of a war with Russia, weekly German magazine Der Spiegel reported.
San Francisco, CA, February 17, 2025 – OpenAI announced on Friday that its AI agent, Operator, is now available for ChatGPT Pro subscribers in a broader range of countries, including Australia, Brazil, Canada, India, Japan, Singapore, South Korea, and the United Kingdom, among others.
Peru - the roof of a food court collapsed, killing at least 3 people and injuring 74 others.
Start your day informed with AnewZ Morning Brief: here are the top news stories for February 22nd, covering the latest developments you need to know.
Australia has accused China of failing to provide sufficient notice ahead of a live-fire naval drill between Australia and New Zealand, forcing airlines to alter flight paths. Defence Minister Richard Marles described the lack of communication as “disconcerting” for commercial aviation.
BERLIN, Feb 22 (Reuters) - NATO is planning to build a pipeline system from Germany to Poland and the Czech Republic to ensure a rapid supply of jet fuel for fighter aircraft in the event of a war with Russia, weekly German magazine Der Spiegel reported.
Menlo Park, CA, February 17, 2025 – Newly unsealed court documents from the case Kadrey v. Meta shed light on internal discussions among Meta employees about the use of copyrighted materials to train the company’s artificial intelligence models.
California Governor Gavin Newsom is asking Congress for nearly $40 billion in disaster funding to help Los Angeles recover and rebuild areas scorched by last month's devastating wildfires, the Washington Post reported on Friday citing a letter.
San Francisco, February 17, 2025 – OpenAI has terminated a group of Chinese ChatGPT accounts that were reportedly used to edit and debug code for an AI-powered social media surveillance tool.
‘We are already negotiating to work together in space, we can collaborate in this sphere also," Russian leader says
A tragic crowd crush at New Delhi Railway Station on Saturday night left 18 dead and 10 injured as thousands of people, many heading to the Kumbh Mela festival, attempted to board delayed trains. The incident highlights the ongoing risks of overcrowding at public transportation hubs in India.
A Delta Air Lines regional jet flipped upside down upon landing at Toronto Pearson Airport on Monday, injuring 18 people. Officials are investigating whether strong winds and snow played a role in the incident.
Berlin, February 21, 2025 – German citizens will head to the polls on Sunday, February 23, for a snap general election after the coalition government collapsed late last year.
Vatican City, February 20, 2025 – Pope Francis will not appear in public on Sunday to lead his customary prayer with pilgrims, marking the second consecutive week of absence, the Vatican announced on Saturday.
London, February 17, 2025 – A new analysis by Cancer Research UK has revealed stark inequalities in cancer mortality across the country, with death rates in the most deprived areas nearly 1.6 times higher than in wealthier regions.
Chinese researchers have discovered a new bat coronavirus, HKU5-CoV-2, which shares the same human receptor as COVID-19, raising concerns about potential animal-to-human transmission.
Pope Francis has developed bilateral pneumonia, further complicating his treatment for a respiratory infection, the Vatican said on Tuesday. All public events through Sunday have been cancelled, as the 88-year-old pontiff remains in hospital for ongoing care.
BERLIN, Feb 22 (Reuters) - NATO is planning to build a pipeline system from Germany to Poland and the Czech Republic to ensure a rapid supply of jet fuel for fighter aircraft in the event of a war with Russia, weekly German magazine Der Spiegel reported.
Menlo Park, CA, February 17, 2025 – Newly unsealed court documents from the case Kadrey v. Meta shed light on internal discussions among Meta employees about the use of copyrighted materials to train the company’s artificial intelligence models.
California Governor Gavin Newsom is asking Congress for nearly $40 billion in disaster funding to help Los Angeles recover and rebuild areas scorched by last month's devastating wildfires, the Washington Post reported on Friday citing a letter.
San Francisco, February 17, 2025 – OpenAI has terminated a group of Chinese ChatGPT accounts that were reportedly used to edit and debug code for an AI-powered social media surveillance tool.
‘We are already negotiating to work together in space, we can collaborate in this sphere also," Russian leader says
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